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Senior Biophysical Scientist

Salary £ Competitive
Location London
Mergefield Title {Mergefield Value}
Mergefield Title {Mergefield Value}

This is a Permanent, Full Time vacancy that will close in {x} days at {xx:xx} BST.

Purpose of Role:

As an active member of the Technology and Process Innovation team working on innovative projects, a Senior Biophysical Scientist will support the development of advanced therapy medicinal products (ATMPs) and associated technology for multiple clients and Collaborators working with the CGT Catapult. The role of Senior Biophysical Scientist will interact closely with CGT Catapult teams at the CGT Catapult Braintree and CGT Catapult Edinburgh Centres when required. Specifically the role will involve the application of biophysical principles to provide insights and understanding that support ongoing development and optimisation activities for cell and gene therapy manufacture.


Key Accountabilities:

  • Provide subject matter expertise in biophysics and contribute this to process development, optimisation and digital twin/model development through experimental and theoretical work.
  • Working in a matrix-team environment contribute biophysical expertise and influence the design and planning of laboratory work.
  • Approving experimental plans, witnessing completed experiments in the electronic laboratory notebook, ensuring raw data is processed according to data integrity guidelines and stored according to company policies.
  • Record, analyse and communicate experimental findings in electronic laboratory notebooks, scientific reports, posters and peer-reviewed publications and present results internally and to external collaborators.
  • Enabling the quality and timely delivery of scientific research produced by the laboratory teams for assigned projects through matrix management of scientists and technicians.
  • Production of protocols, plans, risk assessments, SOPs, and documentation to allow development of experimental protocols and transfer to internal manufacture development and/or external clients or designated contract manufacturers.
  • Supporting the business development team as a subject matter expert to facilitate new commercial and collaborative R&D projects.
  • Support the personal development of more junior members of the team through line management responsibilities and matrix management.
  • Act as “super user” for appropriate equipment and provide training to team members from the analytical, process development and manufacturing and clinical teams as required.



  • Extensive and demonstratable experience in biophysics/physical chemistry.
  • Experience in the application of physical theory and mathematical approaches to understand nanoscale and/or biophysical systems.
  • Experience of the application of experimental methodologies for characterization of nanoscale and biophysical systems and their interactions.
  • Experience of multivariate data analysis and/or machine learning.
  • Experience in analysis or chemometric modelling of spectroscopic data is desirable.
  • Exposure to molecular dynamics (MD) simulations and working with relevant subject matter experts is desirable.
  • Awareness of molecular biology and/or analytical chemistry is desirable.
  • Experience of mammalian cell bioprocessing/culture OR working in a multidisciplinary research environment is desirable.


Knowledge / Skills / Competencies:

  • Highly motivated, pragmatic and practical to support the mission of the Cell and Gene Therapy Catapult to accelerate the development of a commercial cell and gene-based therapy industry in the UK.
  • Desire to establish a high profile career within cell and gene sector and the personal drive to help push the sector to be a commercial success.
  • High level interpersonal, oral and written communication skills and emotional intelligence.
  • Ability to work well under pressure, to work independently and to be able to take the initiative when completing tasks.
  • Ambitious, collaborative, driven.
  • Comfortable operating autonomously once goals and objectives are set.
  • Extensive knowledge of intermolecular and surface forces, interactions and their role in nanoscale biological systems.
  • Extensive knowledge of thermodynamics and kinetics in biophysical systems.
  • Knowledge of experimental methodologies for biophysical characterization.
  • Knowledge of biochemistry.
  • A demonstrated interest in complex systems.
  • Knowledge of modelling dynamical systems.
  • Excellent programming skills in a language such as Python, or Matlab.
  • Excellent knowledge of machine learning, multivariate analysis approaches and data analysis in relevant software.
  • Ability to work within a fast-paced matrix-team environment, maintaining a high standard of work.
  • Ability to work quickly and accurately with a strong focus on attention to detail and accuracy, with limited supervision.
  • Keeps up to date with professional knowledge, expertise and best practice.
  • A positive attitude towards learning, personal and professional development.
  • Keeps up to date with professional knowledge, expertise and best practice.
  • Willingness to travel.


Education / Qualifications

  • PhD with 3+ years industrial experience or BSc with 7+ years industrial experience in life sciences or cell and gene therapy.


The Cell and Gene Therapy Catapult was established as an independent centre of excellence to advance the growth of the UK cell and gene therapy industry, by bridging the gap between scientific research and full-scale commercialisation.

With more than 350 employees focusing on cell and gene therapy technologies, it works with partners in academia and industry to ensure these life-changing therapies can be developed for use in health services throughout the world. It offers leading-edge capability, technology and innovation to enable companies to take products into clinical trials and provide clinical, process development, manufacturing, regulatory, health economics and market access expertise. Its aim is to make the UK the most compelling and logical choice for UK and international partners to develop and commercialise these advanced therapies.

The Cell and Gene Therapy Catapult works with Innovate UK. For more information please visit or visit

Career Development Opportunities

Discretionary Performance Related Bonus

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